Loss of the common immune coreceptor BAK1 leads to NLR-dependent cell death.
Identifieur interne : 000115 ( Main/Exploration ); précédent : 000114; suivant : 000116Loss of the common immune coreceptor BAK1 leads to NLR-dependent cell death.
Auteurs : Yujun Wu [République populaire de Chine] ; Yang Gao [République populaire de Chine] ; Yanyan Zhan [République populaire de Chine] ; Hong Kui [République populaire de Chine] ; Hongyan Liu [République populaire de Chine] ; Li Yan [République populaire de Chine] ; Birgit Kemmerling [Allemagne] ; Jian-Min Zhou [République populaire de Chine] ; Kai He [République populaire de Chine] ; Jia Li [République populaire de Chine]Source :
- Proceedings of the National Academy of Sciences of the United States of America [ 1091-6490 ] ; 2020.
Abstract
Plants utilize a two-tiered immune system consisting of pattern recognition receptor (PRR)-triggered immunity (PTI) and effector-triggered immunity (ETI) to defend themselves against pathogenic microbes. The receptor protein kinase BAK1 plays a central role in multiple PTI signaling pathways in Arabidopsis However, double mutants made by BAK1 and its closest paralog BKK1 exhibit autoimmune phenotypes, including cell death resembling a typical nucleotide-binding leucine-rich repeat protein (NLR)-mediated ETI response. The molecular mechanisms of the cell death caused by the depletion of BAK1 and BKK1 are poorly understood. Here, we show that the cell-death phenotype of bak1 bkk1 is suppressed when a group of NLRs, ADR1s, are mutated, indicating the cell-death of bak1 bkk1 is the consequence of NLR activation. Furthermore, introduction of a Pseudomonas syringae effector HopB1, which proteolytically cleaves activated BAK1 and its paralogs via either gene transformation or bacterium-delivery, results in a cell-death phenotype in an ADR1s-dependent manner. Our study thus pinpoints that BAK1 and its paralogs are likely guarded by NLRs.
DOI: 10.1073/pnas.1915339117
PubMed: 33055218
PubMed Central: PMC7604517
Affiliations:
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sort="Kemmerling, Birgit" uniqKey="Kemmerling B" first="Birgit" last="Kemmerling">Birgit Kemmerling</name><affiliation wicri:level="3"><nlm:affiliation>Department of Plant Biochemistry, Eberhard-Karls University, Tübingen 72076, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Plant Biochemistry, Eberhard-Karls University, Tübingen 72076</wicri:regionArea><placeName><region type="land" nuts="1">Bade-Wurtemberg</region><region type="district" nuts="2">District de Tübingen</region><settlement type="city">Tübingen</settlement></placeName></affiliation></author><author><name sortKey="Zhou, Jian Min" sort="Zhou, Jian Min" uniqKey="Zhou J" first="Jian-Min" last="Zhou">Jian-Min Zhou</name><affiliation wicri:level="1"><nlm:affiliation>State Key Laboratory of Plant Genomics, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing 100101, China.</nlm:affiliation><country xml:lang="fr">République populaire de 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sort="Gao, Yang" uniqKey="Gao Y" first="Yang" last="Gao">Yang Gao</name><affiliation wicri:level="1"><nlm:affiliation>Ministry of Education Key Laboratory of Cell Activities and Stress Adaptations, School of Life Sciences, Lanzhou University, Lanzhou 730000, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Ministry of Education Key Laboratory of Cell Activities and Stress Adaptations, School of Life Sciences, Lanzhou University, Lanzhou 730000</wicri:regionArea><wicri:noRegion>Lanzhou 730000</wicri:noRegion></affiliation></author><author><name sortKey="Zhan, Yanyan" sort="Zhan, Yanyan" uniqKey="Zhan Y" first="Yanyan" last="Zhan">Yanyan Zhan</name><affiliation wicri:level="1"><nlm:affiliation>Ministry of Education Key Laboratory of Cell Activities and Stress Adaptations, School of Life Sciences, Lanzhou University, Lanzhou 730000, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Ministry of Education Key Laboratory of Cell Activities and Stress Adaptations, School of Life Sciences, Lanzhou University, Lanzhou 730000</wicri:regionArea><wicri:noRegion>Lanzhou 730000</wicri:noRegion></affiliation></author><author><name sortKey="Kui, Hong" sort="Kui, Hong" uniqKey="Kui H" first="Hong" last="Kui">Hong Kui</name><affiliation wicri:level="1"><nlm:affiliation>Ministry of Education Key Laboratory of Cell Activities and Stress Adaptations, School of Life Sciences, Lanzhou University, Lanzhou 730000, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Ministry of Education Key Laboratory of Cell Activities and Stress Adaptations, School of Life Sciences, Lanzhou University, Lanzhou 730000</wicri:regionArea><wicri:noRegion>Lanzhou 730000</wicri:noRegion></affiliation></author><author><name sortKey="Liu, Hongyan" sort="Liu, Hongyan" uniqKey="Liu H" first="Hongyan" last="Liu">Hongyan Liu</name><affiliation wicri:level="1"><nlm:affiliation>Ministry of Education Key Laboratory of Cell Activities and Stress Adaptations, School of Life Sciences, Lanzhou University, Lanzhou 730000, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Ministry of Education Key Laboratory of Cell Activities and Stress Adaptations, School of Life Sciences, Lanzhou University, Lanzhou 730000</wicri:regionArea><wicri:noRegion>Lanzhou 730000</wicri:noRegion></affiliation></author><author><name sortKey="Yan, Li" sort="Yan, Li" uniqKey="Yan L" first="Li" last="Yan">Li Yan</name><affiliation wicri:level="1"><nlm:affiliation>Ministry of Education Key Laboratory of Cell Activities and Stress Adaptations, School of Life Sciences, Lanzhou University, Lanzhou 730000, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Ministry of Education Key Laboratory of Cell Activities and Stress Adaptations, School of Life Sciences, Lanzhou University, Lanzhou 730000</wicri:regionArea><wicri:noRegion>Lanzhou 730000</wicri:noRegion></affiliation></author><author><name sortKey="Kemmerling, Birgit" sort="Kemmerling, Birgit" uniqKey="Kemmerling B" first="Birgit" last="Kemmerling">Birgit Kemmerling</name><affiliation wicri:level="3"><nlm:affiliation>Department of Plant Biochemistry, Eberhard-Karls University, Tübingen 72076, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Plant Biochemistry, Eberhard-Karls University, Tübingen 72076</wicri:regionArea><placeName><region type="land" nuts="1">Bade-Wurtemberg</region><region type="district" nuts="2">District de Tübingen</region><settlement type="city">Tübingen</settlement></placeName></affiliation></author><author><name sortKey="Zhou, Jian Min" sort="Zhou, Jian Min" uniqKey="Zhou J" first="Jian-Min" last="Zhou">Jian-Min Zhou</name><affiliation wicri:level="1"><nlm:affiliation>State Key Laboratory of Plant Genomics, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing 100101, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>State Key Laboratory of Plant Genomics, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing 100101</wicri:regionArea><placeName><settlement type="city">Pékin</settlement></placeName></affiliation></author><author><name sortKey="He, Kai" sort="He, Kai" uniqKey="He K" first="Kai" last="He">Kai He</name><affiliation wicri:level="1"><nlm:affiliation>Ministry of Education Key Laboratory of Cell Activities and Stress Adaptations, School of Life Sciences, Lanzhou University, Lanzhou 730000, China; lijia@lzu.edu.cn hekai@lzu.edu.cn.</nlm:affiliation><country wicri:rule="url">République populaire de Chine</country><wicri:regionArea>Ministry of Education Key Laboratory of Cell Activities and Stress Adaptations, School of Life Sciences, Lanzhou University, Lanzhou 730000</wicri:regionArea><wicri:noRegion>Lanzhou 730000</wicri:noRegion></affiliation></author><author><name sortKey="Li, Jia" sort="Li, Jia" uniqKey="Li J" first="Jia" last="Li">Jia Li</name><affiliation wicri:level="1"><nlm:affiliation>Ministry of Education Key Laboratory of Cell Activities and Stress Adaptations, School of Life Sciences, Lanzhou University, Lanzhou 730000, China; lijia@lzu.edu.cn hekai@lzu.edu.cn.</nlm:affiliation><country wicri:rule="url">République populaire de Chine</country><wicri:regionArea>Ministry of Education Key Laboratory of Cell Activities and Stress Adaptations, School of Life Sciences, Lanzhou University, Lanzhou 730000</wicri:regionArea><wicri:noRegion>Lanzhou 730000</wicri:noRegion></affiliation></author></analytic><series><title level="j">Proceedings of the National Academy of Sciences of the United States of America</title><idno type="eISSN">1091-6490</idno><imprint><date when="2020" type="published">2020</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Plants utilize a two-tiered immune system consisting of pattern recognition receptor (PRR)-triggered immunity (PTI) and effector-triggered immunity (ETI) to defend themselves against pathogenic microbes. The receptor protein kinase BAK1 plays a central role in multiple PTI signaling pathways in <i>Arabidopsis</i> However, double mutants made by <i>BAK1</i> and its closest paralog <i>BKK1</i> exhibit autoimmune phenotypes, including cell death resembling a typical nucleotide-binding leucine-rich repeat protein (NLR)-mediated ETI response. The molecular mechanisms of the cell death caused by the depletion of BAK1 and BKK1 are poorly understood. Here, we show that the cell-death phenotype of <i>bak1 bkk1</i> is suppressed when a group of <i>NLR</i>s, <i>ADR1</i>s, are mutated, indicating the cell-death of <i>bak1 bkk1</i> is the consequence of NLR activation. Furthermore, introduction of a <i>Pseudomonas syringae</i> effector HopB1, which proteolytically cleaves activated BAK1 and its paralogs via either gene transformation or bacterium-delivery, results in a cell-death phenotype in an <i>ADR1</i>s-dependent manner. Our study thus pinpoints that BAK1 and its paralogs are likely guarded by NLRs.</div></front></TEI><pubmed><MedlineCitation Status="In-Data-Review" Owner="NLM"><PMID Version="1">33055218</PMID><DateRevised><Year>2020</Year><Month>11</Month><Day>13</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1091-6490</ISSN><JournalIssue CitedMedium="Internet"><Volume>117</Volume><Issue>43</Issue><PubDate><Year>2020</Year><Month>Oct</Month><Day>27</Day></PubDate></JournalIssue><Title>Proceedings of the National Academy of Sciences of the United States of America</Title><ISOAbbreviation>Proc Natl Acad Sci U S A</ISOAbbreviation></Journal><ArticleTitle>Loss of the common immune coreceptor BAK1 leads to NLR-dependent cell death.</ArticleTitle><Pagination><MedlinePgn>27044-27053</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1073/pnas.1915339117</ELocationID><Abstract><AbstractText>Plants utilize a two-tiered immune system consisting of pattern recognition receptor (PRR)-triggered immunity (PTI) and effector-triggered immunity (ETI) to defend themselves against pathogenic microbes. The receptor protein kinase BAK1 plays a central role in multiple PTI signaling pathways in <i>Arabidopsis</i> However, double mutants made by <i>BAK1</i> and its closest paralog <i>BKK1</i> exhibit autoimmune phenotypes, including cell death resembling a typical nucleotide-binding leucine-rich repeat protein (NLR)-mediated ETI response. The molecular mechanisms of the cell death caused by the depletion of BAK1 and BKK1 are poorly understood. Here, we show that the cell-death phenotype of <i>bak1 bkk1</i> is suppressed when a group of <i>NLR</i>s, <i>ADR1</i>s, are mutated, indicating the cell-death of <i>bak1 bkk1</i> is the consequence of NLR activation. Furthermore, introduction of a <i>Pseudomonas syringae</i> effector HopB1, which proteolytically cleaves activated BAK1 and its paralogs via either gene transformation or bacterium-delivery, results in a cell-death phenotype in an <i>ADR1</i>s-dependent manner. Our study thus pinpoints that BAK1 and its paralogs are likely guarded by NLRs.</AbstractText><CopyrightInformation>Copyright © 2020 the Author(s). Published by PNAS.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Wu</LastName><ForeName>Yujun</ForeName><Initials>Y</Initials><AffiliationInfo><Affiliation>Ministry of Education Key Laboratory of Cell Activities and Stress Adaptations, School of Life Sciences, Lanzhou University, Lanzhou 730000, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Gao</LastName><ForeName>Yang</ForeName><Initials>Y</Initials><AffiliationInfo><Affiliation>Ministry of Education Key Laboratory of Cell Activities and Stress Adaptations, School of Life Sciences, Lanzhou University, Lanzhou 730000, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Zhan</LastName><ForeName>Yanyan</ForeName><Initials>Y</Initials><AffiliationInfo><Affiliation>Ministry of Education Key Laboratory of Cell Activities and Stress Adaptations, School of Life Sciences, Lanzhou University, Lanzhou 730000, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Kui</LastName><ForeName>Hong</ForeName><Initials>H</Initials><AffiliationInfo><Affiliation>Ministry of Education Key Laboratory of Cell Activities and Stress Adaptations, School of Life Sciences, Lanzhou University, Lanzhou 730000, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Liu</LastName><ForeName>Hongyan</ForeName><Initials>H</Initials><AffiliationInfo><Affiliation>Ministry of Education Key Laboratory of Cell Activities and Stress Adaptations, School of Life Sciences, Lanzhou University, Lanzhou 730000, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Yan</LastName><ForeName>Li</ForeName><Initials>L</Initials><AffiliationInfo><Affiliation>Ministry of Education Key Laboratory of Cell Activities and Stress Adaptations, School of Life Sciences, Lanzhou University, Lanzhou 730000, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Kemmerling</LastName><ForeName>Birgit</ForeName><Initials>B</Initials><Identifier Source="ORCID">https://orcid.org/0000-0003-1174-0189</Identifier><AffiliationInfo><Affiliation>Department of Plant Biochemistry, Eberhard-Karls University, Tübingen 72076, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Zhou</LastName><ForeName>Jian-Min</ForeName><Initials>JM</Initials><Identifier Source="ORCID">https://orcid.org/0000-0002-9943-2975</Identifier><AffiliationInfo><Affiliation>State Key Laboratory of Plant Genomics, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing 100101, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>He</LastName><ForeName>Kai</ForeName><Initials>K</Initials><Identifier Source="ORCID">https://orcid.org/0000-0003-0508-8411</Identifier><AffiliationInfo><Affiliation>Ministry of Education Key Laboratory of Cell Activities and Stress Adaptations, School of Life Sciences, Lanzhou University, Lanzhou 730000, China; lijia@lzu.edu.cn hekai@lzu.edu.cn.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Li</LastName><ForeName>Jia</ForeName><Initials>J</Initials><Identifier Source="ORCID">https://orcid.org/0000-0002-3148-6897</Identifier><AffiliationInfo><Affiliation>Ministry of Education Key Laboratory of Cell Activities and Stress Adaptations, School of Life Sciences, Lanzhou University, Lanzhou 730000, China; lijia@lzu.edu.cn hekai@lzu.edu.cn.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2020</Year><Month>10</Month><Day>14</Day></ArticleDate></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>Proc Natl Acad Sci U S A</MedlineTA><NlmUniqueID>7505876</NlmUniqueID><ISSNLinking>0027-8424</ISSNLinking></MedlineJournalInfo><CitationSubset>IM</CitationSubset><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">Arabidopsis thaliana</Keyword><Keyword MajorTopicYN="N">BAK1</Keyword><Keyword MajorTopicYN="N">NLR</Keyword><Keyword MajorTopicYN="N">PRR</Keyword><Keyword MajorTopicYN="N">cell death</Keyword></KeywordList><CoiStatement>The authors declare no competing interest.</CoiStatement></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="pubmed"><Year>2020</Year><Month>10</Month><Day>16</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2020</Year><Month>10</Month><Day>16</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2020</Year><Month>10</Month><Day>15</Day><Hour>17</Hour><Minute>21</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId 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name="République populaire de Chine"><noRegion><name sortKey="Wu, Yujun" sort="Wu, Yujun" uniqKey="Wu Y" first="Yujun" last="Wu">Yujun Wu</name></noRegion><name sortKey="Gao, Yang" sort="Gao, Yang" uniqKey="Gao Y" first="Yang" last="Gao">Yang Gao</name><name sortKey="He, Kai" sort="He, Kai" uniqKey="He K" first="Kai" last="He">Kai He</name><name sortKey="Kui, Hong" sort="Kui, Hong" uniqKey="Kui H" first="Hong" last="Kui">Hong Kui</name><name sortKey="Li, Jia" sort="Li, Jia" uniqKey="Li J" first="Jia" last="Li">Jia Li</name><name sortKey="Liu, Hongyan" sort="Liu, Hongyan" uniqKey="Liu H" first="Hongyan" last="Liu">Hongyan Liu</name><name sortKey="Yan, Li" sort="Yan, Li" uniqKey="Yan L" first="Li" last="Yan">Li Yan</name><name sortKey="Zhan, Yanyan" sort="Zhan, Yanyan" uniqKey="Zhan Y" first="Yanyan" last="Zhan">Yanyan Zhan</name><name sortKey="Zhou, Jian Min" sort="Zhou, Jian Min" uniqKey="Zhou J" first="Jian-Min" last="Zhou">Jian-Min Zhou</name></country><country name="Allemagne"><region name="Bade-Wurtemberg"><name sortKey="Kemmerling, Birgit" sort="Kemmerling, Birgit" uniqKey="Kemmerling B" first="Birgit" last="Kemmerling">Birgit Kemmerling</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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